Evaluation of the Efficacy and Threshold of Serum Anti-Mullerian Hormone Levels for Diagnosis and Prediction of Polycystic Ovary Syndrome Among Indian Women

January 2022 in “ Research Square (Research Square) ”

Sajad Sumji, Abid Bhat, Aafia Rashid, Imtiyaz Ahmad Wani, Vishnu Vasudevan, Tajali Sehar, Mohd Ashraf Ganie

Anti-mullerian Hormone AMH Polycystic Ovary Syndrome PCOS LH/FSH ratio ovarian follicles

TLDR Serum AMH levels are a strong marker for diagnosing PCOS in Indian women.

The study evaluated the diagnostic potential of serum Anti-mullerian Hormone (AMH) levels in Polycystic Ovary Syndrome (PCOS) among 113 Indian women with PCOS and 75 normo-ovulatory women. The results showed that the mean serum AMH level was significantly higher in the PCOS group (7.84±3.67 ng/mL) compared to the control group (3.23 ±1.56 ng/mL). Serum AMH levels positively correlated with the LH/FSH ratio and the number and volume of ovarian follicles, but not with age or BMI. The study determined a cut-off of 3.76 ng/mL for AMH levels, with 86.7% sensitivity and 62.7% specificity. The conclusion is that serum AMH levels could be a potent diagnostic marker of ovarian dysfunction in PCOS, either alone or in conjunction with other tools, to ensure timely diagnosis and early treatment of the disorder.

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