Evaluating the Efficacy of Negative Pressure Wound Therapy in Reducing Surgical Site Infections: A Systematic Review

    July 2025 in “ Journal of Investigative Dermatology ”
    B. Kamaraj, Hariharan Nagarajan, Jyotsna Singh, Y. Velkumar, Ajit Singh, N. Vishwanath
    Studysummary Negative Pressure Wound Therapy reduces surgical site infections and speeds up healing. Our plain-language summary of this paper — not a Tressless recommendation.
    This systematic review assessed the efficacy of Negative Pressure Wound Therapy (NPWT) in reducing surgical site infections (SSIs) and improving wound care outcomes. The review included 8 high-quality randomized controlled trials with 1,196 patients, focusing on conditions like diabetic foot ulcers and post-arthroplasty wounds. NPWT was compared to traditional dressings, showing significant improvements in reducing infection rates and accelerating wound healing (p < 0.05). The therapy also promoted epithelialization and reduced complications such as blister formation and seromas. While NPWT shows promise, further research is needed to confirm its effectiveness in dermatology-specific surgical contexts.
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