A Comparative Study on the Efficacy and Safety of 10% Topical Minoxidil Versus 5% Topical Minoxidil in the Treatment of Male Pattern Hair Loss

June 2024 in “ QJM ”

Mahinaz El-sayed Ali El-sayed, Nermeen Samy Abdel Fattah, Ahmed Abdelfattah Afify

10% topical minoxidil 5% topical minoxidil male pattern hair loss MPHL frontal total hair count side effects patient compliance patient tolerance Rogaine

TLDR 10% minoxidil improves frontal hair count more than 5% but has more side effects.

This study compared the efficacy and safety of 10% topical minoxidil versus 5% topical minoxidil in treating male pattern hair loss (MPHL) over 6 months with 51 patients. The results showed that the 10% minoxidil group had a significantly higher improvement in frontal total hair count compared to the 5% group. However, other parameters of hair growth were similar between the two groups. Despite the higher efficacy in frontal hair count, the 10% concentration was associated with more side effects, which could affect patient compliance and tolerance.

View this study on academic.oup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 5 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community New study shows that microneedling is an ineffective hair loss treatment

in Research/Science 2 years ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 130 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 3 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community 1.25mg of Fin and 5% topical minoxidil once a day. 8 months progress. Diffuse thinning

in Progress Pictures 458 upvotes 3 years ago

This user experienced improvements in their hair density and texture through the use of finasteride (1.25mg) and minoxidil (5%) applied topically once a day over 8 months, with no reported side effects other than slightly lowered libido.

community Homemade topical spironolactone

in Research/Science 27 upvotes 3 years ago

The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

Related Research

8 / 8 results

research Role Of Oral Minoxidil In The Treatment Of Androgenetic Alopecia

February 2024 in “Cosmoderma”

Low-dose oral minoxidil can help treat male and female pattern hair loss, especially in those who can't use topical treatments or have heart health issues.

research Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety

59 citations , July 2020 in “Journal of The American Academy of Dermatology”

Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.

research Deterioration of Scalp Environment by Exogenous Factors and Its Influence on Hair Growth Promoting Effect of Minoxidil

February 2020 in “The Pharmaceutical Society of Japan”

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.