Histopathological Effects of Anabolic Androgenic Steroids (Nandrolone Decanoate) on Heart, Liver, and Kidney of Male Local Rabbits

This study investigated the histopathological effects of the anabolic steroid nandrolone decanoate on the heart, liver, and kidneys of adult male rabbits. Six rabbits were divided into two groups: a control group and a treatment group receiving 10 mg/kg of nandrolone decanoate via intramuscular injection for 15 days. Histological analysis revealed significant structural alterations in the heart, liver, and kidneys of the treated rabbits, including inflammatory cell infiltration, vacuolar degeneration, necrosis, and vascular congestion in the heart; inflammatory cell infiltration, vacuolar degeneration, bile duct hyperplasia, fibrosis, and sinus congestion in the liver; and vacuolar degeneration, glomerular atrophy, congestion, urinary space expansion, and cyst formation in the kidneys. The study concludes that nandrolone decanoate has harmful effects on these organs, recommending caution in its use.