Drug News and Therapeutic News

    June 2023 in “ Fundamental & clinical pharmacology ”
    Pascale Vergne Salle, ; Loupret, Caroline Victorri‐Vigneau, ; Grall-Bronnec
    Image of study
    TLDR JAK inhibitors help treat some diseases but may increase risks of blood clots and cancer in certain patients.
    JAK inhibitors, a new class of synthetic targeted therapies, have shown efficacy in treating conditions like rheumatoid arthritis, alopecia areata, and ulcerative colitis. While Phase III and IV studies suggest their adverse event risk is similar to biological treatments, the Oral Surveillance study highlighted increased risks of thromboembolism and cancer with tofacitinib in older rheumatoid arthritis patients with cardiovascular risk factors. However, observational studies in the U.S. did not confirm these risks. Baricitinib also showed increased thromboembolism risk in various studies. The European Medicines Agency recommended avoiding JAK inhibitors in high-risk patients unless no alternatives exist. Further studies are needed to evaluate the safety of more selective JAK inhibitors like upadacitinib and filgotinib.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 47 results

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       7 upvotes 8 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 9 months ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

    Related Research

    1 / 1 results