Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite
April 2007
in “
Therapeutic Drug Monitoring
”
TLDR Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
A study conducted 16 years ago found that finasteride, a drug used for hair loss and prostate issues, can affect urinary steroid profiles and potentially mask steroid abuse in sports drug testing by impacting steroid metabolism. The study examined the impact of finasteride on urinary steroid profiles for doping control and discovered that it is a synthetic steroid used to treat benign prostatic hyperplasia, alopecia, and acne. The study found that finasteride can affect steroid detection in doping-control analysis by reducing the production of certain steroids and suppressing the excretion of a major metabolite. The study recommends including finasteride in doping control analysis to prevent its misuse in sports.
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Cited in this study
8 / results
research Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): Three- and 4-year results
Finasteride increases hair weight and count in men with hair loss, with best results after four years.
research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia
5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.
research Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia
Steroidogenic isoenzymes may help improve treatments for common hair loss.
research Male androgenetic alopecia
DHT, a testosterone byproduct, causes male pattern baldness.
research Separation of finasteride and analogues
Finasteride and analogues separated using LC-MS-MS technique.
research Clinical application of 5α-reductase inhibitors
5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.
research Finasteride, a Type 2 5α-reductase inhibitor, in the treatment of men with androgenetic alopecia
Finasteride effectively treats male hair loss, improving growth and density.
research Finasteride
Finasteride treats enlarged prostate, improves urinary flow, but may cause sexual side effects.
Related
1 / results
research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.
Finasteride doesn't affect hormone levels in normal men.