TLDR Docetaxel is effective against various cancers but mainly causes neutropenia.
Docetaxel (Taxotere) was reviewed for its preclinical and clinical profiles, showing significant activity in various cancers, including breast, lung, ovarian, and head and neck cancers. In phase I studies, the major dose-limiting toxicity was neutropenia, with other side effects like mucositis, hypersensitivity reactions, neurotoxicities, cutaneous reactions, alopecia, and asthenia. Phase II trials confirmed its efficacy, with neutropenia as the principal side effect. Hypersensitivity reactions were common but manageable with premedication. Ongoing studies aimed to optimize its use in combination regimens and to mitigate side effects.
7 citations
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January 1993 in “Rheumatology” Most skin rashes in rheumatoid arthritis patients were not caused by their medication, and careful evaluation allowed most to keep taking their beneficial treatment.
January 2023 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” The article concludes that schoolchildren and adolescents experienced various skin issues during the COVID-19 pandemic, including acne from masks and other skin reactions from the virus and vaccines.
April 2018 in “Asian-Australasian journal of bioscience and biotechnology” The study concluded that tick infestation was the most common skin problem in hospitalized dogs in Chennai, with various treatments used for different conditions.
15 citations
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December 2014 in “Dermatology and therapy” Sorafenib can cause facial acne-like eruptions, which improve after reducing the dose or stopping the drug.
44 citations
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January 2002 in “American Journal of Clinical Dermatology” Skin reactions to antidepressants are common but usually not serious and can be treated.
47 citations
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January 2003 in “American Journal of Clinical Dermatology” Mood stabilizers can cause serious skin reactions; careful monitoring and immediate treatment are crucial.
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