Dermatological Side Effects of Epidermal Growth Factor Receptor Inhibitors: 'Pride' Complex
January 2014
in “
Indian Journal of Dermatology
”
Studysummary This study reported that EGFR inhibitor therapy in lung and head/neck cancer patients was associated with acneiform eruptions and severe skin dryness, which rarely necessitate discontinuation of treatment and can be managed symptomatically.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Epidermal growth factor receptor (EGFR) inhibitors, used in treating non-small cell lung cancer and head and neck malignancies, were associated with dermatological side effects known as the PRIDE complex, which included papulopustules, paronychia, hair growth abnormalities, itching, and dryness. In a study involving 15 patients, the primary skin-related issues observed were acneiform eruptions and severe skin dryness (xerosis). These side effects typically did not necessitate stopping the cancer treatment and could be managed with symptomatic care.
