Dermatological Side Effects of Epidermal Growth Factor Receptor Inhibitors: 'Pride' Complex

January 2014 in “ Indian Journal of Dermatology ”

Uday Khopkar, Bhushan Madke, Prachi Gole, Prabhash Kumar

epidermal growth factor receptor inhibitors EGFR inhibitors papulopustules paronychia hair growth abnormalities xerosis acneiform eruptions skin dryness itching

TLDR EGFR inhibitors can cause skin issues like acne and dryness, but these can be managed without stopping treatment.

Epidermal growth factor receptor (EGFR) inhibitors, used in treating non-small cell lung cancer and head and neck malignancies, were associated with dermatological side effects known as the PRIDE complex, which included papulopustules, paronychia, hair growth abnormalities, itching, and dryness. In a study involving 15 patients, the primary skin-related issues observed were acneiform eruptions and severe skin dryness (xerosis). These side effects typically did not necessitate stopping the cancer treatment and could be managed with symptomatic care.

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research The PRIDE Syndrome: Dermatological Side Effects of EGFR Inhibitors

90 citations , August 2006 in “British Journal of Dermatology”

PRIDE syndrome includes skin and hair issues from cancer treatment with EGFR inhibitors.

research Differences in Human Skin Between the Epidermal Growth Factor Receptor Distribution Detected by EGF Binding and Monoclonal Antibody Recognition

114 citations , September 1985 in “Journal of Investigative Dermatology”