Common Dermatologic Disorders in Down Syndrome: Systematic Review

September 2021

Megan Lam, Justin D. Lu, Levi Elhadad, Cathryn Sibbald, Raed Alhusayen

alopecia areata atopic dermatitis hidradenitis suppurativa syringomas dermatologic disorders Down syndrome autoimmune skin disorders connective tissue skin disorders

TLDR People with Down syndrome have a higher risk of skin disorders and need better screening and treatment.

This systematic review identified an increased prevalence of various dermatologic disorders in patients with Down syndrome (DS), including atopic dermatitis (19.7%), hidradenitis suppurativa (3.2%), alopecia areata (7.4%), and syringomas (21.2%). The study reviewed 40 observational studies and 99 case reports, highlighting the need for improved screening and management guidelines for dermatologic conditions in this population. Early diagnosis and treatment could benefit patients with DS, who are prone to infectious, inflammatory, autoimmune, and connective tissue skin disorders.

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Research cited in this study

2 / 2 results

research Janus Kinase Inhibition in Down Syndrome: Two Cases of Therapeutic Benefit for Alopecia Areata

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