Prediction of the Development of Depression in Patients with Autoimmune Thyroiditis and Hypothyroidism

The study examined 153 patients with autoimmune thyroiditis and hypothyroidism in Western Ukraine, finding significant links between depression and the BDNF gene polymorphism (rs6265). It observed an inverse relationship between depression and levels of BDNF, fT4, and 25-OH Vitamin D, while a direct correlation existed with thyroid-stimulating hormone (TSH) levels. The study concluded that BDNF, TSH, fT4, anti-TPO, and 25-OH Vitamin D levels were important predictors for the risk of developing depression in these patients.