Association Between Serum Brain-Derived Neurotrophic Factor and 25-OH Vitamin D Levels with Vitamin D Receptors Gene Polymorphism (rs2228570) in Patients with Autoimmune Thyroiditis and Hypothyroidism

The study conducted on 153 patients with autoimmune thyroiditis and hypothyroidism in Ukraine found that while there was a significant decrease in brain-derived neurotrophic factor (BDNF) levels in patients with AA and AG genotypes compared to a control group, there was no significant difference in BDNF levels between different Vitamin D receptor (VDR) genotypes within the study group. Additionally, a moderate direct relationship was observed between serum BDNF levels and 25-OH Vitamin D concentration. The VDR gene polymorphism (rs2228570) was not identified as a risk factor for decreased serum BDNF levels.