Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice
September 2008
in “
Genes & Development
”
Research cited in this study
8 / 8 results
research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding
Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion
BMP signaling prevents hair growth by stopping stem cell activation.
research Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells
β-catenin is essential for stem cell activation and proliferation in hair follicles.
research Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis
WNT signaling is crucial for starting mammary gland development.
research Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors
Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.
research Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin
Tcf3 and Lef1 are key in deciding skin stem cell roles.
research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation
Activated LEF/TCF complexes are crucial for hair development and cycling.
research WNT Signaling in the Control of Hair Growth and Structure
The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.