Cylindroma as Tumor of Hair Follicle Origin

The study investigated the origin of cylindromas, benign tumors often found on the scalp and neck, and concluded that they likely originated from hair follicle epithelial stem cells rather than eccrine glands. This conclusion was based on the expression of hair-specific keratins in cylindroma samples from three female patients with Brooke–Spiegler syndrome. The research also highlighted the role of the CYLD gene, a tumor suppressor, in familial cylindromatosis, noting that mutations in this gene led to cylindroma development. Although CYLD protein expression was downregulated in cylindroma epithelium, its presence supported the tumor's follicular origin, but the study did not conclusively determine CYLD's functional role in cylindroma pathogenesis.