Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Curcumin's low solubility and bioavailability limit its effectiveness as a free drug, but incorporating it into nanoformulations significantly enhances its therapeutic potential for wound healing. These nanoformulations, including nanofibers, nanoparticles, nanosprays, and others, improve bioavailability and promote processes like angiogenesis, collagen deposition, and fibroblast proliferation. Controlled-release nanoformulations ensure sustained presence of curcumin at the wound site, with systems like CUR-loaded chitosan nanoparticles in nanofibers extending release time to 240 hours. Additionally, porous structures such as sponges and hydrogels mimic the extracellular matrix, supporting cell attachment and nutrient flow, which are crucial for effective wound healing. The study highlights the promise of curcumin-based nanoformulations in enhancing wound treatment outcomes.