Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

    October 2019 in “ Al Mustansiriyah Journal of Pharmaceutical Sciences ”
    Haneen Subhee Shaheed, Wassan Abdul-Kareem Abbass, Suzan Yousif Jasim
    Studysummary This study found that the CTLA-4 gene polymorphism (rs733618) has no association with polycystic ovarian syndrome in the studied population. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the role of Cytotoxic T-lymphocyte-Associated Antigen-4 (CTLA-4) gene polymorphism (rs733618) in polycystic ovarian syndrome (PCOS) among 60 PCOS patients and 30 healthy women in Baghdad. Using the tetra-primer amplification-refractory mutation system based on real-time polymerase chain reaction (ARMS-qPCR), the study found normal genotyping in both groups. The results confirmed that the CTLA-4 gene polymorphism (rs733618) did not play a role in PCOS.
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