Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

The study, conducted in 2018, investigated the role of Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene polymorphism (rs733618) in Polycystic Ovarian Syndrome (PCOS) among a sample of 60 Iraqi women with PCOS and 30 healthy women. The participants were matched in average age and body mass index (BMI). The researchers used the tetra-primer amplification-refractory mutation system based on real time polymerase chain reaction (ARMS-qPCR) to detect the CTLA-4 gene polymorphism. The results showed normal genotyping for both groups, leading to the conclusion that the CTLA-4 gene polymorphism (rs 733618) does not play a role in PCOS.