Consensus on the use of oral isotretinoin in dermatology - Brazilian Society of Dermatology
November 2020
in “Anais Brasileiros de Dermatologia”
TLDR The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.
The document from the Brazilian Society of Dermatology provides a consensus on the use of oral isotretinoin in dermatology, highlighting its efficacy in treating acne, including scar correction, and its potential use in other conditions such as refractory rosacea, severe seborrheic dermatitis, advanced photoaging, and frontal fibrosing alopecia. The consensus, formed by eight experts using the DELPHI methodology, recommends conventional or low doses of isotretinoin for better adherence and tolerability, with a total approved dose for acne treatment being 120 to 150 mg/kg. It also addresses the management of side effects, laboratory monitoring, and the safety of dermatological procedures during treatment, concluding that isotretinoin does not increase the risk of psychiatric disorders or inflammatory bowel disease. The document emphasizes the need for further research to establish optimal dosing and treatment duration for various dermatological conditions treated with isotretinoin and the careful consideration of its teratogenic risks, especially in women of childbearing age.
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