Congenital Hypotrichosis in Japanese White Strain (JW-NIBS) Rabbits

    January 2000 in “ Journal of Toxicologic Pathology ”
    K. Kánai, Tetsuo Nunoya, Hajime Yazawa, Kazumoto Shibuya, Mieko Ihara, Makoto Mizutani, Fukuo Yui, Sumio Hoshi, Masanori TAJIMA
    Image of study
    TLDR A single recessive gene causes sparse hair in certain Japanese White rabbits.
    Researchers studied a colony of Japanese White strain (JW-NIBS) rabbits with congenital hypotrichosis, finding it was caused by a single autosomal recessive gene, labeled htr. Affected rabbits had sparse, fine, and short hair on their trunks, with wavy hair around the nose and extremities. Histological analysis showed epidermal thickening, sebaceous gland hyperplasia, and abnormal hair development. Despite these changes, keratin composition in the skin was similar to controls, though there was an increase in both proliferating and apoptotic cells in hair bulbs. No differences were observed in T and B lymphocyte numbers in mesenteric lymph nodes between affected and control rabbits.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 24 results

      community Is this Better Than Topical Minoxidil? Topical Diazoxide

      in Research/Science  6 upvotes 9 months ago
      Topical diazoxide may be a promising hair regrowth treatment, especially for those who don't respond to minoxidil, as it activates potassium channels without needing sulfation. It appears safe for topical use, avoiding systemic effects seen in oral use.

      community Creatine is the opposite of minoxidil !

      in Research/Science  319 upvotes 3 months ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community Another transplant or SMP? (Not balding)

      in Transplants  23 upvotes 1 week ago
      The user is considering another hair transplant or scalp micropigmentation (SMP) for a congenital bald spot, but previous transplants were less effective due to scar tissue. Suggestions include using hair fibers, changing hairstyles, or doing nothing, as the spot is not very noticeable.

      community 31M. Just diagnosed with androgenic alopecia. Fears of min.

      in Finasteride/Dutasteride  12 upvotes 3 months ago
      A 31-year-old man with androgenic alopecia is considering treatments like finasteride, minoxidil, and ketoconazole shampoo but is worried about finasteride's side effects. Users recommend starting with finasteride or dutasteride for DHT blocking, suggesting topical solutions to reduce side effects.

    Related Research

    1 / 1 results