Congenital Combined Melanocytic Nevus of the Scalp With Associated Alopecia Areata

August 2012 in “ The American Journal of Dermatopathology ”

Yee‐Kiat Heng, See Ket Ng, Kong-Bing Tan, Joyce Siong‐See Lee

alopecia areata steroid injections congenital combined melanocytic nevus biopsy neurocristic hamartoma AA steroids

TLDR A man with a birthmark on his scalp developed hair loss that improved with treatment, but the link between the birthmark and hair loss was unclear.

In 2013, a case study described a 20-year-old Chinese man with Marfan syndrome who experienced hair loss over parts of his scalp, where a blue-gray plaque was also observed. He developed alopecia areata (AA) in two patches, which improved with steroid injections. A biopsy confirmed a congenital combined melanocytic nevus without signs of AA, but the nevus was too large to remove. This case was unusual because the alopecia associated with the nevus appeared when the patient was 19, rather than at birth. The relationship between the melanocytic lesion and AA was investigated but remained inconclusive. The study emphasized the need to differentiate between combined melanocytic nevus and neurocristic hamartoma due to their similar appearance but different outcomes.

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Research cited in this study

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research Melanocytes: A Possible Autoimmune Target in Alopecia Areata

35 citations, August 2009 in “Journal of the American Academy of Dermatology”

Melanocytes might be targeted by the immune system in people with alopecia areata, but more research is needed.

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Related Research

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research Congenital Combined Melanocytic Nevus of the Scalp With Associated Alopecia Areata

3 citations, August 2012 in “The American Journal of Dermatopathology”

A man with a birthmark on his scalp developed hair loss that improved with treatment, but the link between the birthmark and hair loss was unclear.

research Combined Melanocytic Nevus Presenting with Scalp Alopecia Associated with Alopecia Areata: Coincidence or Causal?

March 2012

A man's scalp hair loss was due to a combined melanocytic nevus and alopecia areata, suggesting a possible link between the two conditions.