Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?

The review discussed the challenges in regenerative medicine, highlighting the inability to regenerate large-scale, multi-tissue defects in humans despite advances in stem cells, bio-engineered scaffolds, and drug delivery. It examined mammalian models, such as primates, rodents, rabbits, and African spiny mice, which exhibit varying regenerative capabilities, like regenerating distal digit tips or ear pinna tissue. The review emphasized the importance of understanding factors like inflammation, immunity, extracellular matrix composition, and cell proliferation in creating a pro-regenerative microenvironment. Insights from these models could guide the development of therapies to enhance human tissue regeneration.