Commitment of Oral-Derived Stem Cells in Dental and Maxillofacial Applications

The document reviewed the potential of oral-derived stem cells in dental and maxillofacial applications, highlighting their ability to differentiate into bone tissues. It focused on various mesenchymal stem cell (MSC) populations from the oral cavity, such as dental pulp stem cells (DPSCs) and newly discovered human periapical inflamed cyst-derived MSCs (hPCy-MSCs), which showed high plasticity towards bone, vascular, and neural phenotypes. The review discussed clinical procedures using these MSCs and biomaterials for improved bone regeneration in dental procedures, emphasizing their proliferation ability and multipotency for tissue regeneration and immunomodulation. It also covered the latest studies on the use and storage of these MSCs for future clinical applications.