Comment on An International Multicenter, Retrospective Cohort Study of 203 Patients with Pediatric Androgenetic Alopecia

April 2025 in “ Journal of the American Academy of Dermatology ”

Lingfeng Pan, Caihong Li

androgenetic alopecia finasteride minoxidil androgen-dependent development metabolic comorbidities Propecia Rogaine

TLDR The study has limitations, and future research should use better methods to improve treatment for children with hair loss.

The commentary on the study of 203 pediatric patients with androgenetic alopecia highlights several limitations that affect the study's validity and clinical applicability. Concerns include the use of off-label treatments like finasteride and minoxidil, with finasteride potentially disrupting androgen-dependent development in children. The study's short follow-up period and reliance on subjective assessments may underestimate adverse effects and overestimate treatment efficacy. Additionally, the study's retrospective design and lack of standardized protocols limit the assessment of metabolic comorbidities. Future research should focus on prospective studies with standardized protocols and consider genetic, metabolic, and environmental factors to improve treatment strategies and outcomes for children with androgenetic alopecia.

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in Research 865 upvotes 7 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 6 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 6 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

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in Research/Science 37 upvotes 1 year ago

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

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In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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