Collagen Immobilization Onto the Surface of Artificial Hair for Improving Tissue Adhesion

January 2000 in “ Journal of Adhesion Science and Technology ”

Koichi Kato, Yoshihito Kikumura, Masaya Yamamoto, Naohide Tomita, Siro Yamada, Yoshito Ikada

collagen type I atelocollagen poly(ethylene terephthalate) photo-induced graft polymerization poly(acrylic acid) graft chains glutaraldehyde L-cell attachment biosafety tissue adhesion PET PAA

TLDR Modified artificial hair with collagen improves tissue adhesion and is safe for long-term use.

Researchers immobilized type I atelocollagen onto poly(ethylene terephthalate) artificial hair to improve tissue adhesion. They used photo-induced graft polymerization with poly(acrylic acid) to create graft chains that complexed with collagen. Surface analysis confirmed successful collagen immobilization, and crosslinking with glutaraldehyde suppressed collagen degradation. Cell culture tests showed good L-cell attachment to the modified hair. In a human volunteer, the modified hair showed no infection or rejection after 1 year and remained well-fixed in the scalp after 3 years, indicating high biosafety and excellent tissue adhesion.

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