Clinical Trial of Topical Application of Mixed Complex Fermented Extracts Encapsulated in Poly-Gamma Glutamic Acid Hydrogel Nanoparticles in Patients with Androgenetic Alopecia
January 2021
in “
대한피부과학회지
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Studysummary In this randomized controlled trial, the topical application of a PGA solution significantly increased hair density in patients with androgenetic alopecia compared to placebo, with no adverse reactions reported over 24 weeks, suggesting its potential as a safe and effective treatment option. Our plain-language summary of this paper — not a Tressless recommendation.
The study evaluated the efficacy and safety of a topical poly-gamma glutamic acid hydrogel nanoparticle-based fermented extract solution (PGA solution) for treating androgenetic alopecia (AGA) in a 24-week, randomized, double-blinded, placebo-controlled trial with 50 participants (36 men and 14 women). Results showed that the PGA solution significantly increased hair density compared to the placebo, with a hair density increase of 7.24±2.52/cm2 versus 1.53±1.39/cm2 in the placebo group (p＜0.0001). The average hair density after 24 weeks was 129.90±23.04/cm2 in the PGA group compared to 115.32±20.35/cm2 in the placebo group. No adverse reactions were reported, suggesting that the PGA solution could be a safe and effective treatment for AGA.
