Report From The Cicatricial Alopecia Colloquium

    Kurt S. Stenn, George Cotsarelis, Vera H. Price
    TLDR More research is needed to understand and treat cicatricial alopecias.
    The 2005 Cicatricial Alopecia Colloquium focused on understanding primary cicatricial alopecias (CICALs), a group of inflammatory hair disorders leading to permanent hair follicle destruction. Despite treatments that manage symptoms, the underlying disease process remained poorly understood. The colloquium highlighted the need for more research into the etiology and pathogenesis of CICALs, emphasizing the role of immune responses, genetic factors, and the sebaceous gland. Discussions included the potential involvement of follicular stem cells, immune privilege loss, and the need for better animal models. The meeting underscored the complexity of CICALs and the necessity for collaborative research to unravel these disorders.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 23 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  97 upvotes 9 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  56 upvotes 8 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Can we get a reality check on PP405?

      in Research/Science  76 upvotes 1 month ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

    Similar Research

    6 / 1000+ results
      The Basic Science of Hair Biology

      research The Basic Science of Hair Biology

      29 citations , September 2012 in “Dermatologic Clinics”
      Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.
      Advances in Hair Diseases

      research Advances in Hair Diseases

      5 citations , November 2008 in “Advances in Dermatology”
      The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.
      Proceedings of the Ninth World Congress for Hair Research 2015

      research Proceedings of the Ninth World Congress for Hair Research 2015

      January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”
      The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.
      Lymphoproliferative Disorders

      research Lymphoproliferative Disorders

      September 1997 in “Journal of The European Academy of Dermatology and Venereology”
      Skin lymphoproliferative disorders are hard to diagnose and often linked to systemic diseases, but most have a good prognosis with accurate diagnosis.