Implications of Chronic Intake of Finasteride for Androgenetic Alopecia in Prostate Carcinoma

April 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Sara Silva, Sílvia Afonso

finasteride androgenetic alopecia 5-alpha-reductase type 2 inhibitor dihydrotestosterone prostate-specific antigen chemopreventive effect Propecia DHT PSA

TLDR Chronic use of 1 mg/day finasteride for hair loss may delay prostate cancer diagnosis by lowering PSA levels.

This document discusses the implications of chronic finasteride use, particularly at a dose of 1 mg/day for androgenetic alopecia, on prostate cancer diagnosis and prevention. Finasteride, a 5-alpha-reductase type 2 inhibitor, reduces dihydrotestosterone levels, which affects both hair follicles and prostate receptors. While finasteride at 5 mg/day is known to lower prostate-specific antigen (PSA) levels by up to 50% and may have a chemopreventive effect on prostate cancer, this study aims to determine if similar effects occur with the 1 mg/day dose used for hair loss. The concern is whether this lower dose also reduces PSA levels, potentially delaying prostate cancer diagnosis, and if it offers any chemopreventive benefits.

View this study on zenodo.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 year ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 676 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

in Finasteride/Dutasteride 206 upvotes 4 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.

community Summary of Procapil video by Haircafe

in Minoxidil 2 upvotes 4 months ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

Related Research

3 / 3 results

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations , May 2003 in “Toxicological Sciences”

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

research Enhancement of Intermittent Androgen Ablation Therapy by Finasteride Administration in Animal Models

February 2003

Finasteride may improve prostate cancer therapy by enhancing testosterone's benefits and reducing risks.

research Effects of the Anti-Androgen Finasteride on 5-Alpha-Reductase Activity in Human Gingival Fibroblasts in Response to Minocycline

15 citations , January 1998 in “Journal of Clinical Periodontology”

Finasteride helps treat hair loss by blocking enzyme activity.