Inhibitory Effects of Cholesterol on Cell Division in Mouse Skin: Physicochemical and Biological Aspects (The Problem of Male Pattern Baldness)

January 1976 in “ International Journal of Environmental Studies ”

Kirsi Setälä

cholesterol male pattern baldness epidermal cells mitotic activity Tween 60 electron microscopy

TLDR Cholesterol may slow cell division and contribute to male pattern baldness.

The study conducted in 1975 demonstrated that applying a mixture of cholesterol and a detergent similar to Tween 60 to mouse skin significantly reduced the mitotic activity of epidermal cells, as indicated by a P-value of less than 0.001. This reduction in cell division led to a decrease in the number of daughter cells. Additionally, electron microscopy and in vitro experiments revealed that an excess of cholesterol on the surface membrane increased its viscosity and rigidity. These findings suggested a potential link between cholesterol's effects on cell division and male pattern baldness.

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community Diffuse hair loss and scalp biopsies

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community Finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

in Research/Science 531 upvotes 9 months ago

The conversation discusses the potential benefits of finasteride (Fin) for lowering cholesterol and reducing cardiovascular disease risk, with users sharing personal experiences and opinions on the medication's effects on health and hair loss. Some users report positive changes in cholesterol levels after taking finasteride, while others are skeptical or joke about its effects.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 6 days ago

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community Going to try and reverse MPB naturally.

in Treatment 55 upvotes 2 years ago

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community Still not sure why men think diet has nothing to do with hair loss when scientific is quite the opposite [Link]

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Diet can influence hair health, but male pattern baldness (MPB) is primarily genetic. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Guys maybe high cholesterol and hair loss are related

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High cholesterol may accelerate hair loss by reducing blood flow and increasing DHT levels. Treatments mentioned include Minoxidil, finasteride, and RU58841.

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