Childhood-Onset Systemic Lupus Erythematosus with Trisomy X and Increased Risk for Bone Complications: A Case Report

    February 2021 in “ Pediatric rheumatology online journal ”
    Susumu Yamazaki, Yasuhiro Akutsu, Asami Shimbo, Masaki Shimizu, Yuko Segawa, Masaaki Mori
    TLDR A girl with lupus and trisomy X has a higher risk of bone problems like avascular necrosis and osteoporosis.
    The document reported a case of a 16-year-old Japanese girl with childhood-onset systemic lupus erythematosus (cSLE) and trisomy X, who experienced severe bone complications, including multifocal avascular necrosis (AVN) and decreased bone mineral density. Despite treatment with various medications, her extremity pain persisted. Elevated plasma levels of factor VIII were detected, suggesting a link to thrombosis and AVN. The case underscored the increased risk of AVN and osteoporosis in cSLE patients with trisomy X, emphasizing the need for vigilant monitoring and management of bone health in these patients.
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