Analysis of Chemotherapy-Induced Peripheral Neuropathy Using the Japanese Adverse Drug Event Report Database

The study analyzed data from the Japanese Adverse Drug Event Report (JADER) database to assess the relationship between anticancer agents and chemotherapy-induced peripheral neuropathy (CIPN). Out of 622,289 reports, 1,883 were related to peripheral neuropathy. It found that drugs like vinblastine, sorbent-based paclitaxel (sb-PTX), oxaliplatin, and bortezomib had high reporting odds ratios for CIPN, indicating a strong association. The median time to CIPN onset varied by drug class, with nab-paclitaxel (nab-PTX) showing a significantly faster onset than sb-PTX. The study emphasized the need for close monitoring, especially after vinca alkaloid administration, and early treatment for patients receiving taxanes or monoclonal antibodies, as they often did not show improvement. Limitations included potential biases in the database and lack of detailed clinical information.