Digoxin-Induced Anemia Among Patients With Atrial Fibrillation And Heart Failure: Clinical Data Analysis And Drug-Gene Interaction Network

    June 2017 in “ Oncotarget ”
    Yubi Lin, Siqi He, Ruiling Feng, Zhe Xu, Wanqun Chen, Zifeng Huang, Yang Liu, Qianhuan Zhang, Bin Zhang, Kejian Wang, Shulin Wu
    Studysummary This study found that digoxin treatment was significantly associated with anemia adverse reactions in patients with atrial fibrillation and heart failure, suggesting a need for caution in its clinical use. Our plain-language summary of this paper — not a Tressless recommendation.
    This study analyzed data from the FDA Adverse Event Reporting System to examine the link between digoxin use and anemia in patients with atrial fibrillation and heart failure. It included 8142 atrial fibrillation patients and 2588 heart failure patients treated with digoxin. The results showed a significant association between digoxin use and anemia, with reporting odds ratios of 1.38 for atrial fibrillation and 1.50 for heart failure patients. The study identified 821 genes associated with digoxin, many involved in iron transport, suggesting a potential mechanism for digoxin-induced anemia. The findings emphasized the need for caution when prescribing digoxin to patients with hematological conditions and suggested further research on its toxicological mechanisms.
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