April 2012 in “Development” Rac1 is crucial for normal hair structure and pigmentation.
73 citations
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May 2009 in “Proceedings of the National Academy of Sciences” Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.
20 citations
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July 2005 in “Experimental dermatology” The fuzzy gene is crucial for controlling hair growth cycles.
88 citations
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May 2005 in “Journal of Dermatological Science” Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
60 citations
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December 2003 in “Journal of Investigative Dermatology” The study examined the expression of Type II Epithelial Keratin 6hf (K6hf) in mouse hair follicles during the anagen stage, finding it in the companion layer, matrix, and medulla, and regulated in a hair-cycle-dependent manner. K6hf was also present in the nail bed epithelium and fungiform papillae of the tongue. The research suggested a partnership between K6hf and keratin 17, as reduced K6hf levels were observed in keratin 17 null hair. The study provided insights into the spatial organization of cellular precursors in the hair matrix and the potential role of Wnt signaling in regulating K6hf expression, highlighting its distinct expression patterns and functional roles in hair and nail tissues.
41 citations
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September 2003 in “Journal of Investigative Dermatology” The study explored the expression of cyclooxygenase (COX) isozymes, particularly COX-2, during hair follicle development and cycling in mice. Overexpression of COX-2 in transgenic mice led to an early onset of the catagen phase and alopecia, characterized by sparse hair and hairless areas, due to elevated prostaglandin E2 (PGE2) levels and sebaceous gland hyperplasia. This disrupted normal hair follicle cycling, with more catagen follicles compared to wild-type mice. Treatment with the COX-2 inhibitor valdecoxib normalized PGE2 levels and prevented alopecia, indicating COX-2's crucial role in hair growth abnormalities and its potential as a target for hair loss treatments.
January 2001 in “Acta Academiae Medicine Militaris Tertiae” K14 expression in young rats differs from adults.
10 citations
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January 2001 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” Lysosomal proteases and cytoplasmic enzymes help hair follicle cells develop and differentiate.
31 citations
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August 2000 in “Journal of Investigative Dermatology” 79 citations
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December 1999 in “Mechanisms of Development” 166 citations
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July 1999 in “American Journal Of Pathology” 130 citations
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December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle melanocytes die during hair regression.
21 citations
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April 1982 in “Genetics Research” The study examined the hair and follicles of mice with the naked (N) gene using various microscopy techniques. It found that in N/+ mice, fibre cuticle cells and sometimes cortical cells were missing during hair growth. In N/N mice, there was a frequent absence of both cuticle and cortical cells throughout the follicle growth phase. Additionally, abnormalities were noted in the deposition of synthesized keratin in the fibres. The study discussed the potential mode of action of the N gene based on these findings.
17 citations
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November 1967 in “American Journal of Anatomy” Hairless mice have longer hair follicles and abnormal structures during the catagen phase.