Characterization of hair follicles in Hirosaki hairless rats with deletion of basic hair keratin genes : enlarged medulla, loss of cuticle and long catagen
January 2008
in “
Medical Entomology and Zoology
”
Related Research
14 / 14 resultsresearch A function for Rac1 in the terminal differentiation and pigmentation of hair
Rac1 is crucial for normal hair structure and pigmentation.
research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice
The study established that the disruption of the Sox21 gene in mice led to a cyclic alopecia phenotype, characterized by progressive hair loss and eventual regrowth. Sox21 was found to be crucial for the differentiation of the hair shaft cuticle, as its absence resulted in the loss of interlocking structures necessary for anchoring the hair shaft, leading to hair loss. Additionally, the expression of genes related to keratins and keratin binding proteins in the hair shaft cuticle was down-regulated in Sox21-null mice. This research highlighted Sox21 as a key regulator of hair shaft cuticle differentiation and provided insights into potential causes of human hair disorders.
research Premature Termination of Hair Follicle Morphogenesis and Accelerated Hair Follicle Cycling in Iasi Congenital Atrichia (fzica) Mice Points to Fuzzy as a Key Element of Hair Cycle Control
The fuzzy gene is crucial for controlling hair growth cycles.
research Hair Cycle-Specific Expression of Versican in Human Hair Follicles
Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles
research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression
research Keratin 14 in skin and hair follicle of rats during postnatal development period
K14 expression in young rats differs from adults.
research Localization of Cathepsins B, D, L, LAMP-1 and .MU.-Calpain in Developing Hair Follicles.
Lysosomal proteases and cytoplasmic enzymes help hair follicle cells develop and differentiate.
research Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice
research Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation
research The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation
research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?
Hair follicle melanocytes die during hair regression.
research The structure of hair and follicles of mice carrying the naked (N) gene
research Catagen in the hairless house mouse
The study examined the catagen phase of the first hair cycle in hairless (hr) mice, focusing on morphological and histochemical aspects. It found that the mutant epithelial column shortened more slowly than normal, resulting in a longer total follicle length at catagen VII, although the hair shaft's position was normal. The keratinization sequence of the mutant club appeared normal, but there was a failure to form an anchoring brush due to variations in cell shapes and fibrils. The inner root sheath extended further than normal, enclosing the club. Additionally, the glassy membrane and connective tissue sheath were abnormally narrow, primarily due to reduced collagen and a narrower band of PAS-positive material.