Central Centrifugal Cicatricial Alopecia

April 2022 in “ Cutis ”

Heath

central centrifugal cicatricial alopecia scarring alopecia inflammatory hair loss hair follicles

TLDR CCCA is a common, scarring hair loss in Black women that needs early detection.

Central centrifugal cicatricial alopecia (CCCA) was identified as the most common form of scarring alopecia in women of African descent, characterized by progressive, scarring, and inflammatory hair loss that leads to permanent destruction of hair follicles. It typically began in the central scalp and spread outward. Early recognition was crucial for managing CCCA, as illustrated by cases of early and late-stage presentations in Black women aged 45 and 43, respectively.

View this study on cdn.mdedge.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin

24 citations , January 2020 in “JAAD Case Reports”

Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.

research Genetic Susceptibility to Alopecia

5 citations , February 2019 in “The New England Journal of Medicine”

Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.

research Central Centrifugal Cicatricial Alopecia: Possible Familial Aetiology in Two African Families from South Africa

15 citations , November 2012 in “International Journal of Dermatology”

The conclusion is that hair loss from CCCA may be genetic and not solely caused by hair grooming practices.

Related Community Posts Join

6 / 113 results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 88 upvotes 1 year ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 6 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 2 years ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

Similar Research

5 / 1000+ results

research Immunopathogenesis of Primary Cicatricial Alopecia

December 2013 in “Research Portal (King's College London)”

Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

Platelet Rich Plasma and Its Use in Hair Regrowth: A Review