Complications of Cataract Surgery in Wistar Rats Undergoing Treatment with Tamsulosin

    October 2018 in “ Experimental and Therapeutic Medicine ”
    Raluca Popescu, Ciprian Ober, Bogdan Sevastre, Marian Taulescu, Mihai Negru, Iulia Melega, Sidonia Bogdan, Cristina Nicula, Ioan Coman
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    TLDR Stopping tamsulosin one month before cataract surgery reduces eye surgery complications in rats.
    The study examined the impact of tamsulosin, a drug for benign prostatic hyperplasia, on cataract surgery complications in 20 male Wistar rats. The rats were divided into four groups with varying tamsulosin treatment schedules. Group 1, which received continuous tamsulosin treatment, experienced the smallest pupillary diameters and the highest frequency of intraoperative floppy iris syndrome (IFIS) complications. Group 3, which had a one-month break from tamsulosin before surgery, showed a significant reduction in IFIS manifestations. The study concluded that the timing of tamsulosin administration is crucial, and discontinuing the drug one month prior to cataract surgery could minimize IFIS-related complications. This finding suggests that preoperative management strategies for patients with BPH may need to be adjusted to improve cataract surgery outcomes.
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