TLDR Newborns with ichthyosis need specific care based on their skin type.
The article discussed the challenges in diagnosing and managing newborns with Mendelian disorders of cornification, commonly known as ichthyosis, which often present unexpectedly in the neonatal period. It highlighted that the initial presentation of these disorders can differ significantly from their later manifestations due to the transition from intrauterine to extrauterine environments. The authors categorized neonatal ichthyosis into several phenotypic groups: exuberant vernix, collodion baby/harlequin ichthyosis, ichthyosiform erythroderma, blistering, and normal skin/xerosis. Recognizing these phenotypes was emphasized as crucial for guiding initial diagnosis and treatment strategies.
11 citations,
January 2010 in “Current problems in dermatology” Ichthyoses are genetic skin disorders that affect the skin's barrier function.
42 citations,
January 2007 in “Pediatric dermatology” Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.
22 citations,
February 2004 in “Journal of pediatric gastroenterology and nutrition” Children with severe ichthyosis and growth failure rarely have nutritional deficiencies or gastrointestinal issues, but may experience chronic dehydration.
18 citations,
January 2020 in “Acta dermato-venereologica” Over 67 genes linked to ichthyosis help improve diagnosis and treatment.
The chapter explains that there are many genetic skin disorders affecting skin cell formation, including both common and rare types.
81 citations,
June 2012 in “European journal of human genetics” Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.
November 2019 in “Harper's Textbook of Pediatric Dermatology” The document is a detailed medical reference on skin and genetic disorders.
November 2023 in “Frontiers in pharmacology” Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.
