Care of the Newborn with Ichthyosis

January 2013 in “ Dermatologic Therapy ”

John A. Dyer, Mary K. Spraker, Mary L. Williams

ichthyosis Mendelian disorders of cornification MeDOC neonatal period phenotypes skin changes vernix collodion baby harlequin ichthyosis HI ichthyosiform erythroderma blistering xerosis newborn skin conditions dry skin

Studysummary This review discusses the varying neonatal presentations of Mendelian disorders of cornification (ichthyosis) based on phenotypic groups but reports no new clinical results; the authors suggest categorizing these presentations to guide diagnosis and treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The article discussed the challenges in diagnosing and managing newborns with Mendelian disorders of cornification, commonly known as ichthyosis, which often present unexpectedly in the neonatal period. It highlighted that the initial presentation of these disorders can differ significantly from their later manifestations due to the transition from intrauterine to extrauterine environments. The authors categorized neonatal ichthyosis into several phenotypic groups: exuberant vernix, collodion baby/harlequin ichthyosis, ichthyosiform erythroderma, blistering, and normal skin/xerosis. Recognizing these phenotypes was emphasized as crucial for guiding initial diagnosis and treatment strategies.

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Research cited in this study

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