Bupropion for the Treatment of Fluoxetine Non-Responsive Trichotillomania: A Case Report

    November 2011 in “ Journal of Medical Case Reports ”
    Rajshekhar Bipeta, Srinivasa Srr Yerramilli
    TLDR Bupropion may help treat trichotillomania when fluoxetine doesn't work.
    A 23-year-old woman with trichotillomania, unresponsive to fluoxetine, showed significant improvement in hair-pulling behavior after being treated with bupropion (up to 450 mg/day) and cognitive behavior therapy. The improvement persisted over a 12-month follow-up, suggesting bupropion as a potential alternative treatment for trichotillomania, particularly for those not responding to SSRIs. Further research, including double-blind placebo-controlled trials, was recommended to confirm these findings.
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