Biological Evidence of Improved Wound Healing Using Autologous Micrografts in a Diabetic Animal Model

The study on 50 male Wistar rats explored the use of autologous micrografts (AMG) for enhancing wound healing in diabetic conditions. The findings revealed that AMG treatment accelerated healing by boosting collagen production, increasing VEGF-A, IL4, and IL10 levels, and reducing TNF-α and oxidative stress. Histopathological analysis showed improved collagen organization and reduced inflammation in micrograft-treated groups. The study concluded that AMGs significantly enhance wound healing by promoting faster tissue regeneration and reducing inflammation, offering a promising therapeutic approach for managing chronic wounds in diabetic patients.