Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

The review discusses the role of bioactive biopolymers in enhancing the healing of chronic wounds, particularly diabetic ulcers, by leveraging their innate bioactivity and biodegradability. It emphasizes the importance of understanding the structure-function relationship of these biopolymers, as their bioactivity is influenced by structural properties such as molecular weight and amino acid sequences. The review highlights the need for careful characterization of biopolymers like alginate, chitosan, hyaluronic acid, and collagen to optimize their immunomodulatory, anti-bacterial, and anti-oxidant properties, thereby improving tissue regeneration outcomes in diabetic wound healing.