BH15 Nonsyndromic Hypotrichosis: A Rare Case of Congenital Hypotrichosis 15 and Management with Minoxidil

This article discusses a rare case of congenital hypotrichosis 15, a condition characterized by sparse hair growth due to a genetic mutation in the C3orf52 gene. The study focuses on a 2-year-old girl with this condition, who showed some improvement in hair length with the application of topical minoxidil. This supports the potential use of minoxidil in treating congenital hypotrichosis, as it may enhance cell growth, anagen duration, and follicular size. The condition is autosomal recessive and involves reduced 2-acyl-lysophosphatidic acid biosynthesis, affecting hair growth pathways. The case highlights the rarity of the condition, with only nine individuals reported since 2020, and confirms that the genetic mutation results in null alleles, leading to the absence of expected protein expression.