The Efficacy of Baricitinib as a Treatment Option for Alopecia in Terms of Promoting Hair Regrowth and Improving Patient Reported Outcomes

May 2024

Bhaumik Patel, Abhiram Gollapudi, S Gollapudi, Srinidhi Banala, Brian Joseph Mathew, Prince Patel

Baricitinib Janus Kinase inhibitor alopecia hair regrowth Severity of Alopecia Tool SALT score BRAVE-AA1 trial BRAVE-AA2 trial FDA

TLDR Baricitinib effectively promotes hair regrowth in severe alopecia with minimal side effects.

Baricitinib, a Janus Kinase inhibitor, has demonstrated significant efficacy in promoting hair regrowth in patients with severe alopecia, as evidenced by improved Severity of Alopecia Tool (SALT) scores in the BRAVE-AA1 and BRAVE-AA2 trials. Patients treated with Baricitinib showed a marked improvement in SALT scores and a higher proportion achieved an absolute SALT score of ≤10 within 36 weeks compared to placebo, with minimal adverse effects reported. The FDA has approved Baricitinib for treating severe alopecia, but further research is needed to assess its long-term safety and confirm these findings in a larger cohort.

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Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

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research Hair Loss

August 2021 in “Pharmacy Today”

The document's conclusion about hair loss cannot be determined.