Real-Life Effectiveness and Safety of Baricitinib in Adults with Alopecia Areata: A Multicenter Study

    March 2025 in “ Journal of the European Academy of Dermatology and Venereology ”
    A Mourtada, C. Douarec, Matthieu Wargny, V. Hébert, Z. Reguiaï, P. Joly, Julien Séneschal, C. Toussaint, H. Aubert, M. Le Moigne, C. Bernier, Thierry Passeron, C. Jacobzone Leveque, Pascal Reygagne, S. Le Naour, C. Berthin, C. Bara, Maxime Fouchard, R. Janela‐Lapert, M. Masson Regnault, M.B. Duval, M. Jachiet, M. Fenot, H. Adamski, Marie-Emeline Marniquet, S. Barbarot
    From the encyclopedia
    Baricitinib →

    JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

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    Studysummary In a retrospective multicenter cohort study, this research observed that baricitinib was effective and well-tolerated in treating adult patients with alopecia areata, including those with severe cases, showing promise in improving outcomes over a 12-month period with manageable side effects.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    This multicentre study involving 99 adult patients with alopecia areata (AA) across 13 centers found that baricitinib, at a dosage of 4 mg per day, was effective in reducing hair loss, with 75.5% of patients achieving a SALT50 response at 12 months. Patients with an initial SALT score <50 and those receiving baricitinib with systemic corticosteroids showed a higher likelihood of a good response. Adverse events occurred in 21.1% of patients, with acneiform rash being the most common, but no severe adverse events were reported. The study concludes that baricitinib is a well-tolerated and effective treatment for AA, even in refractory cases, though larger studies are needed to evaluate long-term safety and effects of treatment withdrawal.
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