Autoimmune Hepatitis Due to Para-Aminobenzoic Acid

    October 2020 in “ ˜The œAmerican journal of gastroenterology ”
    Eric Lorio, Karthik Garapati, Amy E. Schindler, Fermin O. Tio
    TLDR Para-aminobenzoic acid in hair supplements can cause autoimmune hepatitis.
    A 37-year-old female with ulcerative colitis developed autoimmune hepatitis (AIH) after taking a hair supplement containing para-aminobenzoic acid (PABA). Despite initial treatment with prednisone, her liver function tests (LFTs) worsened, peaking at AST 2310 U/L and ALT 3061 U/L. A liver biopsy confirmed acute hepatitis, and elevated anti-SMA and serum IgG levels supported the AIH diagnosis. She was treated with prednisone and azathioprine, which normalized her LFTs. One year later, she remained asymptomatic on azathioprine. This case highlighted PABA as a previously unreported cause of drug-induced AIH, emphasizing caution with its use.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 19 results

      community Revalid hair complex against hair thinning?

      in Product  3 upvotes 3 months ago
      A 17-year-old with thinning hair is considering using Revalid, a supplement with ingredients like biotin and zinc, based on parental recommendations. Another user suggests that supplements could help since the hair thinning doesn't seem to be androgenic alopecia.

      community Pérdida de cabello en jóvenes (15-20 años) mi experiencia.

      in Treatment  20 upvotes 4 months ago
      A 19-year-old shares his hair loss experience and treatment routine, which includes 1mg finasteride daily, 2mg oral minoxidil daily, ketoconazole shampoo every 2 days, and a healthy lifestyle. He notes that oral minoxidil is showing better results than topical minoxidil.

      community does lowering your prolactin levels regrow hair?

      in Research/Science  10 upvotes 1 year ago
      The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

      community bro where tf is GT20029, Q1 2024 is over already

      in Research/Science  43 upvotes 8 months ago
      The conversation discusses the delay in the release of GT20029 for hair loss treatment and skepticism about its effectiveness. Participants mention other treatments like verteporfin and advancements in transplant procedures as more realistic options.

    Similar Research

    5 / 1000+ results
      Westwood Carolina Conference on Clinical Dermatology

      research Westwood Carolina Conference on Clinical Dermatology

      July 1980 in “Journal of The American Academy of Dermatology”
      The conference concluded that understanding hair and nail disorders is important, iron deficiency may be linked to hair loss, and while some treatments for skin conditions are effective, they may have risks and high costs.
      The Scientific Legacy of Stephen Rothman

      research The Scientific Legacy of Stephen Rothman

      6 citations, November 2014 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      Stephen Rothman made important discoveries in dermatology, including the use of PABA in sunscreens, but never profited from his work.
      Common Topical Medications

      research Common Topical Medications

      October 2018 in “Springer eBooks”
      The document concludes that various topical medications are effective for skin conditions but often cause skin irritation as a side effect.