Long-Term Treatment With Apremilast in Hidradenitis Suppurativa: A 2-Year Follow-Up of Initial Responders

    September 2020 in “ Journal of the American Academy of Dermatology ”
    Pim Aarts, Allard R.J.V. Vossen, Hessel H. van der Zee, Errol P. Prens, Kelsey R. van Straalen
    TLDR Apremilast may be a promising long-term treatment for hidradenitis suppurativa.
    The study assessed the long-term efficacy of apremilast for hidradenitis suppurativa (HS) over 2 years. Initially, 53.3% of patients achieved the Hidradenitis Suppurativa Clinical Response (HiSCR) after 16 weeks. In the follow-up, 4 out of 8 initial responders continued treatment and maintained HiSCR at 1 and 2 years. Some patients discontinued due to pregnancy wishes or adverse effects like nausea. Despite the small sample size, the study indicated that apremilast could be a promising long-term treatment for HS, but further research with a larger cohort was necessary.
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