Long-Term Treatment With Apremilast in Hidradenitis Suppurativa: A 2-Year Follow-Up of Initial Responders

    September 2020 in “ Journal of the American Academy of Dermatology ”
    Pim Aarts, Allard R.J.V. Vossen, Hessel H. van der Zee, Errol P. Prens, Kelsey R. van Straalen
    TLDR Apremilast may be a promising long-term treatment for hidradenitis suppurativa.
    The study followed initial responders from a randomized controlled trial of apremilast for hidradenitis suppurativa (HS) over 2 years. Initially, 53.3% of patients met the Hidradenitis Suppurativa Clinical Response (HiSCR) after 16 weeks of treatment. Of the 8 initial responders, 4 continued treatment for 2 years, all achieving HiSCR at follow-up visits. Two patients discontinued due to pregnancy wishes, and others due to side effects or symptom remission. Despite manageable side effects, 75% of participants would recommend apremilast. The study suggested prolonged efficacy of apremilast for HS, but emphasized the need for larger studies to confirm long-term benefits.
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