Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in anin vitroorgan culture system
March 2007
in “International Journal of Dermatology”
TLDR Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.
In the 2007 study, researchers explored the use of antisense oligonucleotides targeting FGFR-1 to stimulate hair follicle activity as a potential treatment for baldness. They treated cultured mouse hair follicles with a 20-mer antisense nucleotide and observed a dose-dependent increase in cellular activity in the hair bulb, with the highest stimulation at 30 µM. Although the increase in fluorescence intensity was 30%, it was not statistically significant. The hair bulb's morphological structure remained intact after treatment, and the oligonucleotide was incorporated into the follicular papilla. The findings suggested that FGFR-1 targeting antisense nucleotides might be useful for treating baldness, but further in vivo studies were needed to assess their clinical application.
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