Antimalarial Therapy for Granuloma Annulare: Results of a Retrospective Analysis

This retrospective analysis reviewed 35 histologically confirmed granuloma annulare (GA) cases from the University of Pennsylvania between 2009 and 2016. The study found that 55.6% of patients treated with hydroxychloroquine and 100% of those treated with chloroquine showed improvement, with an average treatment duration of 3.6 and 3 months, respectively. The cohort had a higher prevalence of comorbidities such as glucose intolerance (63.2%), dyslipidemia (80%), and thyroid disease (37%) compared to the general population. The study highlighted the potential association of GA with thyroid disease and suggested that antimalarials could be considered as first-line treatment for generalized GA. Limitations included the small sample size and retrospective nature of the study.