Anti-DFS70 as a Marker of Non-Systemic Autoimmune Events (Primary Biliary Cholangitis) in Systemic Lupus Erythematosus

June 2020 in “ Jurnal Penyakit Dalam Indonesia ”

Yasjudan Rastrama Putra, Deshinta Putri Mulya, Fahmi Indrarti

systemic lupus erythematosus primary biliary cholangitis anti-dense fine speckled 70 antibodies hair loss ursodeoxycholic acid SLE PBC anti-DFS70 antibodies UDCA

TLDR Anti-DFS70 antibodies can help identify nonsystemic autoimmune conditions in SLE patients.

The document discussed a case of a 40-year-old woman diagnosed with systemic lupus erythematosus (SLE) who also exhibited primary biliary cholangitis (PBC) features. The patient presented with symptoms such as fatigue, loss of appetite, icteric, arthralgia, hair loss, and fever. Laboratory tests showed elevated bilirubin, gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) levels, along with positive anti-dense fine speckled 70 (DFS70) antibodies. Magnetic resonance cholangiopancreatography (MRCP) confirmed PBC. Treatment with ursodeoxycholic acid (UDCA) normalized ALP and GGT levels within two months. The case highlighted the importance of evaluating anti-DFS70 findings in SLE patients for potential nonsystemic autoimmune conditions.

View this study on jurnalpenyakitdalam.ui.ac.id →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 7 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 8 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 6 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

Similar Research

5 / 1000+ results

research Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis

291 citations, January 2014 in “The Scientific World Journal”

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

research Alopecia Areata, Primary Sclerosing Cholangitis, and Ulcerative Colitis: Autoimmunity and Apoptosis as Common Links?

11 citations, March 2007 in “Digestive Diseases and Sciences”

The conditions alopecia areata, primary sclerosing cholangitis, and ulcerative colitis may be linked by shared autoimmune and cell death mechanisms.

Comprehensive Overview of Rheumatology Studies: Ottawa, Ontario, Canada, February 13–16, 2013