TLDR Cyclosporine-A can cause excessive hair growth, which usually stops after discontinuing the drug.
The document discussed a case of cyclosporine-A (CSA) induced hypertrichosis in a patient with hemophagocytic lymphohistiocytosis (HLH). Hypertrichosis, characterized by excessive hair growth, was linked to the administration of CSA, a potent immunosuppressive drug used in the HLH-2004 treatment protocol. The patient exhibited diffuse hypertrichosis and eyelash trichomegaly, likely exacerbated by concurrent steroid therapy. Although hypertrichosis is a recognized side effect of CSA, it is usually not clinically significant and resolves after stopping the medication. The mechanism behind CSA-induced hair growth was speculated to involve the modulation of protein kinase C, which affects cell proliferation. The case highlighted the idiosyncratic nature of this side effect, as it does not occur universally in all patients.
24 citations,
May 2012 in “International Journal of Dermatology” The document concludes that eyelash trichomegaly, which is the abnormal growth of eyelashes, can be present from birth, caused by diseases, or result from certain medications.
45 citations,
September 2001 in “Journal of Investigative Dermatology” Cyclosporin A promotes hair cell growth and affects protein kinase C levels.
2 citations,
October 2018 in “Springer eBooks” Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.
10 citations,
February 2015 in “Clinics in Dermatology” The document concludes that changes in eyelashes and eyelid skin can indicate various local and systemic diseases.
22 citations,
September 2004 in “Journal of The European Academy of Dermatology and Venereology” Bimatoprost can cause longer, thicker, darker eyelashes and eyebrows.
4 citations,
November 2021 in “Cancers” The document concludes that understanding and managing hair loss in cancer patients is important, and more research is needed for better treatments.
7 citations,
May 2014 in “Clinical practice” Cooling the scalp may prevent hair loss from chemotherapy, hair often grows back after treatment, and nail issues usually improve after stopping the drug.
