Androgenetic Alopecia: Understanding Its Pathogenesis and Treatment Advancements

    Sardar Parvin Mahamad1*, Mr. Sunil Dongre2, Dr. Ganesh Tolsarwad3
    TLDR New treatments for androgenetic alopecia are emerging, improving hair loss management.
    Androgenetic alopecia (AGA) is the most common form of nonscarring hair loss, with recent advancements in understanding its pathogenesis leading to more effective treatments. The article discusses the genetic basis of AGA and the role of stem cells in its development. Diagnosis can now be aided by Trichoscopy, and while traditional treatments like topical minoxidil, systemic Finasteride, and hair transplants remain prevalent, new treatment modalities are being explored. The article also addresses the psychosocial impact of AGA and its association with cardiovascular conditions, noting that men are more frequently affected by this systematic hair loss.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 3 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Am I missing something with pp405?

      in Research/Science  34 upvotes 1 year ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

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