A Case of Androgen-Secreting Adrenal Carcinoma with Non-Classical Congenital Adrenal Hyperplasia
January 2013
in “
Indian Journal of Endocrinology and Metabolism
”
TLDR A woman with a rare adrenal tumor and hormonal disorder had improved testosterone levels after surgery, but her menstrual irregularities continued.
In 2013, a case study was presented of a 42-year-old woman with a rare androgen-secreting adrenocortical carcinoma (ACC) and non-classical congenital adrenal hyperplasia (CAH). The patient experienced secondary amenorrhea, hirsutism, and virilization, and was found to have a large adrenal mass. Her hormonal profile showed elevated levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S), leading to the diagnosis. After surgical removal of the tumor, her testosterone levels normalized, but amenorrhea persisted. This case was unique due to the rarity of pure androgen-secreting adrenal tumors and the simultaneous presence of non-classical CAH. The study highlighted the importance of detailed history, clinical examination, hormonal workup, and radiological evaluation in diagnosing hyperandrogenism with hirsutism and virilization in females.
