Androgen Receptor Blockade Induces the Phagocytosis of MRSA and Pseudomonas Aeruginosa by Monocyte-Derived Macrophages In Vitro

    September 2025 in “ e-space (Manchester Metropolitan University) ”
    Belboul, Amina, El Mohtadi, Mohamed, Fadel, Abdulmannan, Mcloughlin, Jessica, Mahmoud, Ayman M, O’Malley, Caitlin, Ashworth, Jason
    TLDR Blocking androgen receptors helps immune cells better fight certain bacteria.
    The study explores how blocking androgen receptors affects the phagocytic activity of monocyte-derived macrophages against MRSA and Pseudomonas aeruginosa in vitro. Results indicate that androgen receptor blockade enhances macrophage phagocytosis of these bacteria, suggesting a potential therapeutic approach for infections by these pathogens. The research highlights the role of androgen receptors in modulating immune responses, but does not detail the number of samples or participants involved.
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